T cell subsets rise again

T helper cell differentiation: on again, off again.

Recent studies raise the possibility that T helper (Th) polarization may be attributable to generalized activation and regulated silencing rather than regulated activation of target cytokine genes. The binding of transcription factors GATA-3 or T-bet to specific enhancers does recruit transcription factors such as NFAT-1 to IL-4 or IFNgamma promoters, respectively; however, GATA-3 also intrinsi...

imbalance of t-cell subsets in iranian allergic rhinitis patients

r'iwenty-nine patients were studied to determine the number of cj).j+ tscell subsets in iranian allergic rhinitis patients. the result was compared with that a/twenty-four nonatopic controls. the number of11 and cds+t cell')and levels ofspeafic ige and /g(;4 against weed pollens were also studied the number of lymphocyte subset, tltat is, cd-/+ c/)29+and c1jf cj)451t cells were determined hy do...

The Immunomodulatory Effect of Cyclophosphamide on Regulation of T-Cell Subsets and Antigen Presenting Cells.

Modulation of CD4+ T Cell Subsets by Euphorbia microciadia and Euphorbia osyridea Plant Extracts

Background: Euphorbia plants are traditionally used in folk medicine for infections, inflammation, and cancer. Objectives: To investigate the effects of the butanolic extracts of Euphorbia micorociadia and Euphorbia osyridea on specific transcription factors and cytokines expression of T cell subsets. Methods: Activated mouse splenocytes were cultured in the presence of non-cytotoxic concentrat...

Cd4+ T Cell Subsets during Virus Infection

To analyze the antiviral protective capacities of CD4(+) T helper (Th) cell subsets, we used transgenic T cells expressing an I-A(b)-restricted T cell receptor specific for an epitope of vesicular stomatitis virus glycoprotein (VSV-G). After polarization into Th1 or Th2 effectors and adoptive transfer into T cell-deficient recipients, protective capacities were assessed after infection with dif...